Lipinski's Rule Of Five

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Lipinski's Rule Of Five

In general, an orally active drug has:

not more than 5 Hydrogen Bond donors (OH and NH groups)

not more than 10 hydrogen bond acceptors (notably N and O )

a Molecular Weight under 500

a LogP under 5

Lipinski's work has since been extended to include properties such as the number of rings and rotatable bonds.

REFERENCES

CA Lipinski, ''Adv. Drug Del. Rev.'' 1997 , 23, 3

EXTERNAL LINKS

Interactive Rule of Five calculator