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Langerhans Cell




Generally, dendritic cells in Tissue (such as Langerhans' cells) are active in the capture, uptake and processing of antigens. Once dendritic cells arrive in secondary lymphoid tissue however, they lose these properties while gaining the capacity to interact with naive T-cells.

In the rare Disease Langerhans' Cell Histiocytosis (LCH), these cells are being excessively produced and cause damage to Bone s.

Langerhans' cells are derived from the Cellular Differentiation of monocytes with the marker "Gr-1" (also known as "Ly-6c/G"). The differentiation requires stimulation by Colony Stimulating Factor -1 (PMID 16444257).


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