Jan Piotr Sapieha (1569-1611) starosta uświacki, pułkownik królewski, father of Jan Paweł Sapieha
Jan Stanislaw Sapieha (1589-1635), Chancellor of Lithuania from 1621-1635, childless
Jan Paweł Sapieha (1609/1610–1665), father of Jan Kazimierz the Younger, voivod of Wilno and (since 1656) the Grand Hetman of Lithuania.
Jan Kazimierz Sapieha The Younger , (ca. 1637/1642–1720), since 1700 held the title of a Duke. Since 1681 Field Hetman of Lithuania, the following year he also became the Voivod of Wilno . In 1682 promoted to Grand Hetman of Lithuania.
