- Internet Service Provider , an organization that offers users access to the Internet and related services.
- Information Systems Professional , an Information Technology title and post-nominal. Proper usage is "I.S.P.".
- In-System Programming , a way to configure programmable logic devices while they are installed in a larger system.
- Islip/Long Island MacArthur Airport , ISP being the IATA Airport Code for it.
- Independent Solutions Provider , provides solutions associated with a product or a final service to the client.
- Specific Impulse , represented by ''Isp'', term used to describe rocket thrust.
- Illinois State Police, Law enforcement agencies across Illinois.
- The Invisibl Skratch Piklz , a pioneering group of turntable artists in the early 1990s that featured notable DJs such as Mix Master Mike and DJ Q-bert .
- International School Of Paris , A multicultural school situated a couple minutes away from the Eiffel Tower.
- At New College Of Florida , an ISP is an Independent Study Project
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