- Formally, can refer to '' International Sign Language '', aka Gestuno.
- Informally, can refer to Irish Sign Language .
- More formally, is the SIL Code for Israeli Sign Language .
- is the NATO Country Code for Iceland .
- In mathematics, can stand for In The Sense Of Lyapunov .
- In reference to a Storage Area Network , and switched networks stands for Inter Switch Link .
- ISL may also stand for the proprietary Cisco Inter-Switch Link protocol.
- ISL can refer to the Independent School League , a group of 16 New England Preparatory Schools .
- ISL can refer to the Independent School League , a group of 17 Washington, DC -area Preparatory Schools .
- ISL can refer to the Independent School League , a group of 9 Illinois Preparatory Schools .
- ISL was an initialism for the British based Ice Hockey Superleague (1996–2003)
- ISL can refer to the security firm Intercon Security
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