Information AboutIcam-1 |
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During the acute stages of Inflammation , Homeostasis is altered, resulting in the Cytokine stimulated release of ICAMs which promote Leukocyte adherence to the Endothelium . The CAMs are involved with leukocyte adhesion at relatively low shear forces and they cause a stronger attachment than selectin molecules. There are several different forms of ICAM. ICAM-1 is continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, Macrophages and Lymphocytes . ICAM-1 has been implicated in Subarachnoid Hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. While ICAM-1 has not been shown to be directly correlated with cerebral Vasospasm , a secondary insult which affects 70% of SAH patients, treatment with anti-ICAM-1 reduced the severity of vasospasm. Exposed on the cell surface, ICAM-1 serve as binding receptor for Rhinovirus , the most common cause of viral respiratory tract infections. EXTERNAL LINK REFERENCES
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