- Anthony Hughes , a British judge
- Anthony Hughes (actor) , a British actor
- Anthony James Hughes , a recipient of the Queen's Service Medal in 2006
- Arthur Hughes (artist) (1831-1915), an American Painter
- Arthur Hughes (actor) (1894-1982), an American Actor and Radio Personality
- Charles Evans Hughes (1862-1948), United States Secretary Of State and Chief Justice Of The United States
- Dave Hughes (born 1970), an Australian stand-up comic
- David E. Hughes (1831-1900), an American Academic , Inventor and Musician
- David Hughes (novelist) , a British Novelist
- David Hughes (cricketer) (born 1947), a British Cricketer
- Dorothy B. Hughes (1904-1993), U.S. crime writer
- Edward James Hughes, aka Ted Hughes (1930-1998), British Poet Laureate
- Howard Hughes (1905-1976), an American Aviator , Filmmaker and Industrialist
- James Hughes , an American Sociologist , Bioethicist , and Democratic Transhumanist philosopher
- John Hughes (archbishop) (1797-1864), first Roman Catholic Archbishop Of New York
- John Hughes (English Politician) , a former British Member Of Parliament
- John Hughes (film Director) (born 1950), an American film director, writer, and producer
- Langston Hughes (1902-1967), an American Poet
- Mark R. Hughes , ( 1956 - 2000 ), an American Entrepreneur , a founder of Herbalife
- Matt Hughes (writer) , a Canadian Science Fiction writer
- Matt Hughes (fighter) , an American professional Mixed Martial Arts fighter
- Robert Hughes ''disambiguation page''
- Sarah Hughes (born 1985), an American Figure Skater and Olympic gold medalist
- Sarah T. Hughes (1896-1985), US District Judge who administered oath of office to President Lyndon Johnson
- Thomas Hughes (1822-1896), English lawyer, writer, and politician
- Yolanda Hughes , American Female Bodybuilder
- Steven "No Competition" Hughes , Steel Factory Supervisor and resident of St. Clair Shores ghetto, exiled from Downriver
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