The first ''Southampton'' was a 48 gun 4th rate launched in 1693. The ship was rebuilt in 1700, hulked in 1728 and finally broken up in 1771.
The second ''Southampton'' was a 32 gun 5th rate launched in 1757. The ship was wrecked off the Bahamas in 1812.
The third ''Southampton'' was a 60 gun 4th rate that was launched in 1820. In 1867 the ship was lent to the Hull Committee, finally being sold in 1912.