Information AboutGram-negative |
| CATEGORIES ABOUT GRAM-NEGATIVE | |
| gram negative bacteria | |
| staining | |
| bacteriology | |
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Many species of Gram-negative bacteria are Pathogenic , meaning they can cause disease in a host organism. This pathogenic capability is usually associated with certain components of Gram-negative cell walls, in particular the Lipopolysaccharide (also known as LPS or Endotoxin ) layer. CHARACTERISTICS The following characteristics are displayed by Gram-negative bacteria: #Cell walls only contain a few layers of Peptidoglycan (which is present in much higher levels in Gram-positive bacteria) #Cells are surrounded by an Outer Membrane of lipopolysaccharide outside the peptidoglycan layer #Porins exist in the outer membrane, which act like pores for particular molecules #There is a space between the layers of peptidoglycan and the secondary cell membrane called the Periplasmatic Space #The S-layer is directly attached to the outer membrane, rather than the peptidoglycan #If present, Flagella have four supporting rings instead of two #No Teichoic Acid s are present EXAMPLE SPECIES The Proteobacteria are a major group of Gram-negative bacteria, including '' Escherichia Coli '', '' Salmonella '', and other Enterobacteriaceae , '' Pseudomonas '', '' Moraxella '', '' Helicobacter '', ''Stenotrophomonas'', '' Bdellovibrio '', Acetic Acid Bacteria , '' Legionella '' and many others. Other notable groups of Gram-negative bacteria include the Cyanobacteria , Spirochaete s, Green Sulfur and Green Non-sulfur bacteria. Medically relevant Gram-negative Cocci include three organisms, which cause a Sexually Transmitted Disease (''Neisseria gonorrhea''), a Meningitis ('' Neisseria Meningitidis ''), and respiratory symptoms ('' Moraxella Catarrhalis ''). Medically relevant Gram-negative Bacilli include a multitude of species. Some of them primarily cause respiratory problems ('' Hemophilus Influenzae '', ''Klebsiella pneumoniae'', ''Legionella pneumophila'', '' Pseudomonas Aeruginosa ''), primarily urinary problems (''Escherichia coli'', ''Proteus mirabilis'', ''Enterobacter cloacae'', ''Serratia marcescens''), and primarily gastrointestinal problems ('' Helicobacter Pylori '', '' Salmonella Enteritidis '', '' Salmonella Typhi ''). THE OUTER MEMBRANE One of the several unique characteristics of gram-negative bacteria is the Outer Membrane . This outer membrane is responsible for protecting the bacteria from several Antibiotic s, dyes, and Detergent s which would normally damage the inner membrane or cell wall ( Peptidoglycan ). Because of the outer membrane, these bacteria are resistant to Lysozyme and Penicillin . Fortunately, alternative medicinal treatments such as lysozyme with EDTA and Ampicillin have been developed to combat the protective outer membrane of pathogenic Gram-negatives. REFERENCES |
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