- Eddie Cantor , stage and film star
- Eddie Cheever , American race car driver
- Eddie Cochran , American rockabilly musician
- Eddie Guardado , American baseball closer
- Eddie Guerrero , late American professional wrestler of Hispanic extraction
- Eddie Irvine , British Formula One driver
- Eddie Izzard , British stand-up comedian and actor
- Eddie McGuire , CEO of Nine Network , Australia and former television presenter
- Eddie Murphy , African-American comedian, singer and actor
- Eddie Paskey , U.S. actor primarily known for his mostly uncredited role as "Lieutenant Leslie" in the original Star Trek
- Eddie Van Halen , guitarist and songwriter
- Eddie Vedder , frontman of the band Pearl Jam
- Eddie , canine character in the sitcom ''Frasier''
- Eddie , character in the ''Fusion'' comic book
- Eddie , minor character from The Hitchhiker's Guide to the Galaxy
- Eddie , character from the ''Guilty Gear'' video game series
- Eddie The Head , the mascot of the British heavy metal band Iron Maiden
- Eddie Gordo , character in the video game series ''Tekken''
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