- Danish Touring Car Championship
- Doctoral Training Centre
- The Delhi Transport Corporation (DTC), the Transportation backbone of Delhi .
- The Depository Trust Corporation , a division of the USA Clearing House DTCC .
- Direct To Consumer , the sale of goods without intermediary third parties.
- Data Trouble Code , in software engineering for diagnostic purposes stored error codes (e.g. automotive).
- Distributed Transaction Coordinator , in Microsoft Servers for a subsystem concerned with Atomic Transactions across multiple datastores
- Domain Technologie Control , a Web-based control panel for admin and accounting for hosting web and e-mail services
- Diagnostic Trouble Code , in the automotive industry, codes that are prescribed by SAE standards to help track problems in a vehicle detected by its on-board computer
- DTC is also the stock symbol of Domtar Incorporated on the New York Stock Exchange
- Denver Technological Center , a business park located on I-25 in Denver and Greenwood Village, Colorado
- Diamond Trading Company , the world's largest marketer of rough diamonds (a company within the De Beers group).
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