- DMX (rapper) (born 1970), alias for Earl Simmons, an African-American rapper/hip hop performer and actor
- DMX (lighting) ("Digital Multiplex" or DMX-512), a lighting communications protocol
- DMX Krew , alias for Ed Upton, an electronic music artist
- DMX Music , formerly "Digital Music Express", a subscription service that provides music in digital format in a variety of transmission modes
- DMX Sound Library , a Sound Library used in the popular video game ''Doom''
- Dextromethorphan or DXM (commonly mistaken as DMX in abbrieviation), an antitussive (anti-coughing) drug that is found in many over-the-counter cold and cough preparations
- 5-dehydro-m-xylylene , (DMX), the first known organic molecule to break Hund's Rule
- Distributed Multiheaded X
- Data Mining Extensions , a query language for data mining models defined in the OLEDB for DM standard
- Data Management, Exploration and Mining group in Microsoft Research
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