Information AboutCurtius Rearrangement |
| CATEGORIES ABOUT CURTIUS REARRANGEMENT | |
| rearrangement reactions | |
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The isocyanate can be trapped by a variety of Nucleophile s. Often water is added to Hydrolyze the isocyanate to an Amine . When done in the presence of Tert-butanol , the reaction generates BOC - Protected amines, useful intermediates in Organic Synthesis . Carboxylic Acid s 1 can be easily converted to acyl azides '''3''' using Diphenylphosphoryl Azide '''2'''. Likewise, when the Curtius reaction is performed in the presence of Benzyl Alcohol , Cbz-protected amines are formed. REFERENCES |
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