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Clemmensen Reduction




Several reviews have been published.

The Clemmensen reduction is particularly effective at reducing Aryl - Alkyl ketones. With Aliphatic or acyclic ketones, Zinc metal reduction is much more effective.

The substrate must be stable in the strongly acidic conditions of the Clemmensen reduction. Acid sensitive substrates should use the Wolff-Kishner Reduction , which utilizes strongly basic conditions.


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