| Cholinesterase Inhibitor |
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Anticholinesterases occur naturally as Venoms and Poison s, are used as weapons in the form of Nerve Agent s, and are used medicinally to treat diseases such as Myasthenia Gravis and Alzheimer's Disease , and as an antidote to Anticholinergic poisoning. In myasthenia gravis, they are used to increase neuromuscular transmission. Compounds which function as Reversible Competitive or Noncompetitive Inhibitor s of cholinesterase are those most likely to have therapeutic uses. These include:
Compounds which function as Quasi-irreversible Inhibitor s of cholinesterase are those most likely to have use as Chemical Weapon s or Pesticide s. These include:
Some major effects of anticholinesterase: Actions on the autonomic nervous system, that is parasympathetic nervous system will cause bradycardia, hypotension, hypersecretion, bronchoconstriction, GIT hypermotility, and decrease intraocular pressure. Actions on the neuromuscular junction will result in prolonged muscle contraction. SEE ALSO |
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