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He travelled extensively through Central and South America, and published a number of books on cacti, including the six-volume 4,000-page ''Die Cactaceae'', 1958-1962, and the ''Kakteenlexikon'' first appearing in 1966 and updated posthumously.

Although he collected and described many new species and defined a number of new genera, much of his work was based on faulty assumptions about the evolution of cacti, and too focused on geographic distribution; many of his genera have since been reorganized or abandoned.