The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as:
- Cancer
- Muscular and neurological diseases
- Immune and inflamatory responses
- Cystic Fibrosis
Born in Karcag , Jász-Nagykun-Szolnok county, Hungary , he received his M.D. in 1965 and his Ph.D in 1969 from the Hadassah Faculty Of Medicine of Hebrew University in Jerusalem . He is currently a Distinguished Professor at the Rappaport Family Institute for Research in Medical Sciences at the Technion (Israel Institutite of Technology) in Haifa and Adjunct Professor of Pathology at New York University .
- 1987 - Weizmann Prize for Sciences (Israel)
- 1993 - Elected to the European Molecular Biology Organization
- 1994 - Israel Prize in Biochemistry and Medicine
- 1999 - Wachter Prize, by the University of Innsbruck, Austria (with A. Ciechanover)
- 1999 - Gairdner International A ward, by the Gairdner Foundation, Canada (with A. Varshavsky)
- 2000 - Albert Lasker Award for Basic Medical Research
- 2004 - Nobel Prize in Chemistry
- Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP". ''Proc. Natl. Acad. Sci. USA'' 76, pp. 3107-3110.
- Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". ''Proc. Natl. Acad. Sci. USA'' 77, pp. 1783-1786.
- Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982) Covalent affinity purification of ubiquitin-activating enzyme. J. Biol. Chem. 257, 2537-2542.
- Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206-8214.
- Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619-1623.
- Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
- Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
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