- family of which 2C-T-2 , 2C-T-7 , 2C-I , and 2C-B are most well known. Additionally, Shulgin performed seminal work into the descriptive synthesis of compounds based on the organic compound Tryptamine .
After his creation of a series of successful (and profitable) patents for Dow Chemical , Shulgin left Dow to pursue his own interests, and became a private consultant, also frequently teaching graduate classes in the local universities. Through his friend Bob Sager, head of the DEA 's Western Laboratories, Shulgin formed a relationship with the DEA and began holding pharmacology seminars for the agents, supplying the DEA with samples of various compounds, and occasionally serving as an expert witness in court; he also authored a definitive law enforcement reference book on controlled substances and received several awards from the DEA.
Through this work, he obtained a DEA Schedule I license, allowing him to posess and synthesize any otherwise illicit drug. Shulgin set up a chemical synthesis laboratory in a small building behind his house, which gave him a great deal of career autonomy. Shulgin used this freedom to synthesize and test the effects of Psychoactive Drug s. After judicious self-experiments, he enlisted a small group of friends with whom he regularly tested his creations. They had a systematic way of ranking the effects of the various drugs, known as the Shulgin Rating Scale , with a vocabulary to describe the visual, auditory and physical sensations. He personally tested hundreds of drugs, mainly analogues of various Phenethylamine s (family containing MDMA , and Mescaline ), and Tryptamine s (family containing DMT and Psilocybin ). There are a seemingly infinite number of slight chemical variations, all of which produce variations in effect--some pleasant and some unpleasant--and all of which are meticulously recorded in Shulgin's books.
Two years after the publication of ''PiHKAL'', the DEA raided his lab; finding problems with his record keeping, the DEA requested that Shulgin turn over his license for violating the license's terms. Two earlier, unnanounced reviews during the over 15 years in which Shulgin held his license, both before the publication of ''PiHKAL'', had failed to find any irregularities. Richard Meyer, spokesman for DEA's San Francisco Field Division, has stated that "It is our opinion that those books are pretty much cookbooks on how to make illegal drugs. Agents tell me that in clandestine labs that they have raided, they have found copies of those books," suggesting that the publication of ''PiHKAL'' and the termination of Shulgin's license are not unrelated.
Some of the more interesting chemicals mentioned in Shulgin's books include DiPT ( Diisopropyltryptamine ), which appears to almost exclusively affect the sense of hearing. Perceived frequencies of sounds are shifted down nonlinearly (as opposed to each pitch shifting the same amount), which indicates that the drug might affect cortical processing areas rather than the ear itself.
He currently works at home in Lafayette , CA , and is writing a new comprehensive psychedelic drug index.
- with Wendy Perry. ''The Simple Plant Isoquinolines''. Berkeley: Transform Press, 2002. 0963009621
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- with Ann Shulgin. ''''. Berkeley: Transform Press, 1991. 0963009605
- ''Controlled Substances: Chemical & Legal Guide to Federal Drug Laws'', Berkeley: Ronin Publishing, 1988. 091417150X
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