| Aldosterone |
Articles about Aldosterone |
Information AboutAldosterone |
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| mineralocorticoids | |
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Aldosterone is responsible for the reabsorption of about 2% of filtered sodium in the kidneys, which is nearly equal to the entire sodium content in human blood under normal GFR ( Glomerular Filtration Rate ).Sherwood, L. Human Physiology, from Cells to Systems, 4th Ed., Brooks/Cole, 2001 Unlike Neuroreceptor s, classic Steroid receptors are intracellularly located. The aldosterone/MR receptor complex binds on the DNA to the Hormone Response Element , which alters Protein Synthesis and the Transcription of Messenger RNA . Some of the transcribed genes are important for Transepithelial Sodium Transport , including Serum And Glucocorticoid-induced Kinase , Channel-inducing Factor , K-ras2A , and three Subunit s of the Epithelial Sodium Channel . Aldosterone synthesis is stimulated by increased Plasma Angiotensin II or Potassium levels, which are present in proportion to plasma sodium deficiencies. It is also stimulated by plasma acidosis. The secretion of aldosterone has a Diurnal rhythm; about 75% of the daily production is secreted between 04:00 am and 10:00 am each day.Hurwitz S, Cohen R, & Williams GH. ''Diurnal variation of aldosterone and plasma renin activity: timing relation to melatonin and cortisol and consistency after prolonged bed rest.'' 2004 J Appl Physiol 96: 1406-1414. Full Text ALDOSTERONE AND THE KIDNEY Control of aldosterone release
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