('''5-ARD''') is a condition caused by a
Mutation of the
5-alpha Reductase type 2
Gene . This gene encodes an
Enzyme that converts
Testosterone to
Dihydrotestosterone (DHT). DHT is necessary for the development of male
Genitalia in utero, and the resulting DHT deficency results in ambiguous external genitalia at birth. The condition affects only chromosomal males (i.e., those with XY
Chromosome s). Individuals with 5-ARD lack a
Uterus and
Fallopian Tube s (due to the normal action of
Mullerian Inhibiting Factor ), and possess
Testicles and
Wolffian Structures . Their external genitalia, however, can vary from normal male external genitalia, to
Ambiguous Genitalia , to normal female genitalia (although with a tendency towards an enlarged
Clitoris ). In the later cases the
Wolffian Duct s terminate in the
Perineum or in a
Pseudovagina . 5-ARD constitutes a variety of
Intersexualism .
Individuals with 5-ARD have XY chromosomes and testicles, and tend to have a
Vagina and
Labia , but with a small
Penis capable of ejaculation instead of a clitoris (this penis, however, appears to be a clitoris at birth). These individuals are normally raised as girls. However, come
Puberty , their testes will descend, their voice will deepen and they often will develop a male sexual identity. However, they develop only limited
Facial Hair , and will not experience male-pattern baldness.
