- October 12 - A great storm shifts the mouth of the River Rother 12 miles (20 km) to the west; a battering series of strong storms significantly alter other coastal geography as well (''see Romney Marsh '').
- December 13 - Frederick II, Holy Roman Emperor , dies, beginning a 23-year-long Interregnum known as the . Frederick II is the last Holy Roman Emperor of the Hohenstaufen dynasty; after the interregnum, the empire passes to the Habsburg s.
- The Lombard League dissolves upon the death of its member states' nemesis, Frederick II, Holy Roman Emperor.
- King Afonso III Of Portugal captures the Algarve from the Moors, thus completing the expulsion of the Moors from Portugal .
- Valdemar I Of Sweden , first Swedish king of the Folkung house, becomes King of Sweden
- Albertus Magnus isolates the element Arsenic . He also first uses the word Oriole to describe a type of bird (most likely the Golden Oriole of Great Britain ).
- University Of Valladolid is founded in Spain .
- The Rialto Bridge in Venice, Italy is converted from a pontoon bridge to a permanent, raised wooden structure.
- Vincent Of Beauvais completes his proto-encyclopedic work, ''The Greater Mirror ''.
- The Parlement Law Court s of '' Ancien Régime '' France are established.
- A plague breaks out in the city Naples (In what is now Italy), called the Naple's Plague
The World Population in 1250 is estimated at between 400 and 416 million individuals.
Being a round number, the year 1250 is used to demarcate the beginning or ending of various eras or epochs. These include:
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